Several large epidemiologic studies have suggested adverse metabolic effects resulting from non-nutritive sweeteners especially in the form of diet soda consumption, surprisingly similar to sugar intake. These include weight gain, central adiposity, metabolic syndrome, and cardiovascular disease.
A study published in the American Heart Association journal Stroke, found one daily diet soda puts a person at three times the risk of dementia and stroke compared to someone who drinks less than one a week or none at all. Purdue University found in 2013 diet soda doesn't actually help with weight loss and as a result can lead to stroke due to obesity.
Studies have found that sugar-free sodas are at least as likely as sugary sodas to be linked to the development of metabolic syndrome—a condition that often precedes or accompanies diabetes. Metabolic syndrome is a cluster of conditions that includes high blood pressure, excess belly fat, high triglycerides, low levels of "good" HDL cholesterol, or high fasting blood sugar.
Diet soda is a non-caloric beverage that is sweetened with artificial sweetener, except for the splendor-sweetened version, which is sweetened with both splendor, or sucralose, and acesulfame potassium, and which is also known as Ace K3. These sweeteners in diet coke are non-nutritive and non-caloric. Diet soda also contains caffeine, depending on the quantities consumed. Caffeine is linked to anxiety and sleep disruption when consumed in excess.
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